In gene ontology (GO) enrichment analysis, we observed that KLF2 or KLF15 alteration was associated with multiple biological processes, including cell proliferation (GO:0008283), cell adhesion (GO:0007155), regulation of cell growth (GO:0001558) and regulation of cell cycle (GO:0051726) in breast cancer (Additional file 1: Fig. S3A). The gene discussed is KLF2; the disease is breast cancer.