Downregulation of CDC42 by siRNAs either cognate to the iso-2 or the common region of the iso-1 and iso-2 transcripts (but not by iso-1 specific siRNAs) to the levels mimicking the effect of the miR-10b inhibitor (Fig. 5e and Supplementary Fig. 9a-f), significantly reduced glioma proliferation and growth, as indicated by Ki67 staining, number and size of GSC spheroids, and overall cell viability (Fig. 5f-h and Supplementary Fig. 9a-f). This evidence concerns the gene MKI67 and glioma.