While environmental contaminants and smoking are known to be the risk factors for bladder cancer [3], knowledge about genetic factor contributing to bladder cancer is limited although altered expression for the genes related to cell cycle, transcription and cytoskeleton was well observed in bladder cancer [4]; mutation altering TERT expression was identified in bladder cancer [5]; and differential gene expression was used to classify bladder cancer into sub-groups [6], the mechanisms of the abnormal gene expression in bladder cancer remains largely elusive. The gene discussed is TERT; the disease is urinary bladder cancer.