Except COAD, AML (acute myeloid leukemia), READ, UCS and UVM, the expression of CARM1 is positively correlated with MMRs genes mutation in almost all types of tumors from TCGA, and the results of MLH1, MSH2, MSH6 and PMS2 are more significant (Fig. 7a). The gene discussed is MSH6; the disease is colon adenocarcinoma.