NFKB1 and cancer: Existing studies on exploring the mechanisms of CARM1 methylation affecting tumor progression have shown that CARM1 is a coactivator of several cancer-related transcription factors and can be involved in promoting tumor cell proliferation and metastasis by methylating cancer-related transcription factors, including NF-κB, p53, steroid receptors and so on, and its high expression is associated with poor prognosis of tumors [15].