Based on the results of immune cells infiltration, immune and matrix score as well as co-expression analysis of MMRs, methyltransferases genes and immune checkpoint genes, we found that CARM1 potentially affects the tumor immune microenvironment in most tumors, especially ACC, LUAD, LUSC, STAD, HNSC, THYM, etc. It is a direction worth exploring to clarify how CARM1 affects tumor immunity. This evidence concerns the gene CARM1 and adrenal cortex carcinoma.