PRRX1 and colonic neoplasm: Paired related homeobox 1 (PRRX1) is an important transcription factor of embryonic development and epithelial‐mesenchymal transition (EMT) of the tumor, which is highly expressed in breast, lung, colon tumors, etc. PRRX1b is associated with the invasion of pancreatic cancer cells, while PRRX1a is highly correlated to migration.