To verify the important role of NAP1L2 in vivo, we successfully established a senile osteoporosis model in 24‐month‐old mice and confirmed obvious bone marrow loss in the aged mice using a micro‐CT scan by detecting the microstructure of the femur (Figure 6a), as well as trabecular number (Tb.N), trabecular thickness (Tb. The gene discussed is NAP1L2; the disease is osteoporosis.