In cortical tissue, a genotype/treatment interaction was observed (p = 0.0298, F(1,22) = 5.398; Fig. 6B) and post hoc analysis revealed that IL-10 was significantly increased in 3xTg-AD mice receiving fingolimod compared to vehicle-treated controls (Veh: 60.57 ± 4.04, FTY: 81.58 ± 8.15; p = 0.0277, n = 6–7). The gene discussed is IL10; the disease is Alzheimer disease.