AIF1 and Alzheimer disease: A genotype-related increase in the number of Iba1-positive cells was observed in the CA1 (p = 0.0286, F(1,8) = 7.098; Fig. 3B) and CA3 (p = 0.0076, F(1,8) = 12.56; Fig. 3D) and post hoc analysis revealed that treatment with fingolimod significantly reduced the number of Iba1-positive cells in 3xTg-AD mice (Veh CA1: 0.251 ± 0.006, FTY CA1: 0.201 ± 0.009, p = 0.0174, n = 3; Veh CA3: 0.233 ± 0.012, FTY CA3: 0.169 ± 0.013; p = 0.0151, n = 3).