MAPT and Alzheimer disease: As expected a significant genotype-related increase in total tau protein was observed in the cortex and hippocampus of 3xTg-AD mice by Tau46 antibody (cortex: p = 0.0076, F(1,16) = 9.306; hippocampus: p = 0.0265, F(1,16) = 5.975; Fig. 7A).