We found that other than CA125, none of the other markers provided useful discriminatory information for ovarian cancer detected more than 9 months after blood draw and that paired combinations of CA125 with any other of the 8 markers did not meaningfully improve discrimination compared to CA125 alone, in either the 0–9 or the >9–18 months lag-time intervals. This evidence concerns the gene MUC16 and ovarian carcinoma.