Assessing the interaction of BCL-2 family proteins using immunoprecipitation upon exposure of ALL cells to BH3-mimetics, we observed decreased binding of BIM to BCL-2 upon exposure to venetoclax, but compensational increased binding to MCL-1 (Fig. 7H), as described earlier in other cancer cell types [48, 49, 52, 53]. Here, BCL2 is linked to acute lymphoblastic leukemia.