We identified one such mouse strain harboring a mutation in transmembrane protein 135 (Tmem135FUN025/FUN025) that displays signs of accelerated aging in the retina as well as pathologies observed in AMD including autofluorescent aggregates in the subretinal space, increased inflammation, and thickened retinal pigmented epithelium (RPE) at a young age3. Here, TMEM135 is linked to age-related macular degeneration.