Furthermore, two upregulated genes (Srebf1 and Lss) and two downregulated genes [GATA binding protein 2 (Gata2) and Cyb5a] were common between Tmem135FUN025/FUN025 eyecups and advanced AMD (Table 2 and Fig. 7A). This evidence concerns the gene GATA2 and age-related macular degeneration.