TMEM135 and age-related macular degeneration: There were similar genes affected due to the Tmem135 mutation and AMD (Table 2), including 16 upregulated and 9 downregulated genes in common between the Tmem135FUN025/FUN025 relative to WT RNA-Seq dataset and GSE29801 and GSE135092 datasets (Table 2 and Fig. 7A).