In the past decade, numerous epigenetic modifiers have been used for the clinical treatment of patients with hematologic malignancies, including inhibitors of DNA methyltransferases (DNMTs), enhancers of zeste homolog 2 (EZH2), histone deacetylases (HDACs), and isocitrate dehydrogenases (IDHs) [4]. The gene discussed is EZH2; the disease is hematologic disorder.