PTGDS and Cachexia: In our cachexia mouse model, several of the DE genes enriched in the bulk analysis (Figure 1E, Supplementary Table 3) belong to the top-induced genes in oligodendrocytes (Figure 4A–C), such as Mt1, Sgk1, Klf13, and Ptgds, indicating an important role for oligodendrocytes in the pathology of cachexia.