More evidence for enhanced signaling between oligodendrocytes and other cell types during cachectic stress is provided by the induction of Ptgds. PTGDS is an enzyme which catalyzes the conversion of prostaglandin H2 to the neuromodulator or neuroinflammatory molecule prostaglandin D2 that is in turn known to cause demyelination and astrogliosis, which are commonly observed in neurodegenerative diseases [43]. The gene discussed is PTGDS; the disease is neurodegenerative disease.