It is likely that these myeloid cells and blood borne biomarkers of pancreatic cancer act in symphony to induce some of the observed local changes in the MBH, which is confirmed by the high level of co-regulation between a number of these transcripts (e.g. lrg1, Plin4, Lcn2 and Icam1). This evidence concerns the gene PLIN4 and familial pancreatic carcinoma.