NPY and tuberculosis: Indeed, previous studies demonstrate that hypothalamic neuronal peptides regulating food intake are modulated in cancer cachexia [15], and the scRNAseq data indicate that the anorexigenic Pomc, Cartpt, and Crhr1 were among the most downregulated transcripts in neurons in TB mice, while the orexogenic Npy showed little change (Figure 6A and B).