Here, we show that cranial infusion of LCN2 in WT mice was sufficient to induce some of the main molecular characteristics of cachexia such as endothelial inflammation, microglia activation and upregulation of oligodendrocyte specific genes, such as Plin4. In addition, we observed a robust activation of various components of the immune system, such as increased interleukin signaling, an IFG response and neutrophil degranulation, which is consistent with the described role of LCN2 as a neutrophil chemoattractant [32]. The gene discussed is PLIN4; the disease is Cachexia.