CD44 and malignant colon neoplasm: CD44 has been in the focus of cancer research for decades due to its multiple roles in tumor progression and invasion;35, 36, 37 in particular, CD44 has been described as a mediator of adhesion of prostate and breast cancer cells to bone marrow endothelium38 and as a major E-selectin ligand on breast39,40 and colon cancer cells.41