In a proof-of-principle experiment with one BZM-sensitive xenograft model (3R principle), we observed that BZM “loses” its anti-metastatic effect on HOS xenografts in Sele−/– mice (Figure 3E), while its moderate effect on the HOS xenograft tumor growth (slightly prolonged growth period) known from E-selectin wild-type mice (Figure 2A) was again detectable (Figure 3E). This evidence concerns the gene SELE and neoplasm.