It was observed that the exosome-mediated down-modulation of NKG2D was inhibited by anti-MICA, but not isotype- control Ab, confirming that reduced NKG2D surface expression occurs with tumor but not with non-tumor exosomes, and is at least in part due to exosomal MICA expression [78]. The gene discussed is KLRK1; the disease is neoplasm.