Recently, investigating the effects of oral cancer-derived exosomes (OCEXs) on NKG2D, NKp30, NKp44, NKp46 and NKG2A expression by NK cells, researchers observed that OCEXs significantly upregulate the expression of activating receptors (NKG2D, NKp30, NKp44 and NKp46) on the NK92MI cells for 24 h following treatment, whereas the expression of NKG2A was remarkably decreased at the same timeline [22]. The gene discussed is KLRK1; the disease is lip and oral cavity carcinoma.