We hypothesize that, in addition to decreased sympathetic and renin-angiotensin-aldosterone axis activation associated with subcutaneous fat, this downregulation of triglyceride production, which is corroborated by inverse associations between leg/total% and triglyceride levels in studies assessing metabolic syndrome criteria, leads to decreased endothelial cell damage in arterioles and maintenance of vessel elasticity and compliance. This evidence concerns the gene REN and metabolic syndrome.