In addition, immunohistochemistry (IHC) of the excised tumour sections indicated that the expression of Ki67 (a proliferation marker) and CD44 (an invasiveness marker) in circNEIL3-knockdown tumour tissues was lower than that in the vector group, while circNEIL3 overexpression showed the opposite effects (Fig. 2G). The gene discussed is MKI67; the disease is neoplasm.