Rescue assays showed that IGF2BP3 knockout compensated for the increased proliferation, invasion and migration capacity, as well as upregulation of its downstream targets, caused by exogenous overexpression of circNEIL3 (Fig. S6A-E), indicating that circNEIL3 may regulate the malignant progression of glioma by destabilizing IGF2BP3 proteins. The gene discussed is IGF2BP3; the disease is glioma.