As shown in Fig. S1A, the genes were significantly enriched in many pathways involved in tumour pathogenesis, including cell proliferation regulation pathways (such as cell cycle and DNA replication), pathways associated with tumour invasion and migration (such as focal adhesion and ECM-receptor interaction), and classical signalling pathways involved in tumorigenesis, including p53 signalling pathways and pathways in cancer. This evidence concerns the gene TP53 and cancer.