In addition, the tumor tissues of oe-circ_0000658-treated mice exhibited reduced β-catenin and E-cadherin, as well as elevated N-cadherin, Slug, Snail, ZEB1 and Twist, whereas further inhibition of HMGA2 reversed this effect relative to oe-circ_0000658 alone (Fig. 7D, Fig. S3). This evidence concerns the gene TWIST1 and neoplasm.