TGFB1 and glaucoma: It may therefore be tempting to speculate that, at least in PEX glaucoma, where aqueous TGF-β2 levels were normal [16] but TGF-β1 was elevated [27], there is the potential for further increase in aqueous TGF-β1 induced by ACP/ PI to raise the risk of unfavorable bleb development after surgery than other glaucomas.