CNTN3 and tuberous sclerosis: RNAseq analysis of the contactin-3 family genes revealed CNTN3 as the only significantly down-regulated gene of the contactin family in cortical tubers (log2 fold change = − 1.32, q-value = 0.004, n = 12 TSC vs n = 10 controls) compared to the autopsy-derived control tissue (Supplementary Fig.1).