CNTN3 and Focal cortical dysplasia: Further analysis of RNAseq data showed that CNTN3 was down-regulated (adjusted p-value = 0.05) in the cortical tuber samples obtained from patients of 0–3 years old and a trend for lower CNTN3 was also observed in the 0–3 years group of samples from the patients with focal cortical dysplasia (FCD) type IIB compared to age-matched controls (Fig. 1A).