HOTAIR and pachyonychia congenita: LncRNAs have been extensively reported to be dysregulated in PC, including nuclear paraspeckle assembly transcript 1 (NEAT1), LINC00844, zinc finger homeodomain enhancer-binding protein antisense RNA 1 (ZEB-AS1) and HOX transcript antisense RNA (HOTAIR), which are involved in the progression of PC via multiple mechanisms [29–38].