In this study, SNHG3 was mainly detected in the cytoplasm of PC3 and C4-2B cells, indicating that SNHG3 may promote the development of PC by interacting with miRNA, which is also supported by previous findings on osteosarcoma, acute myeloid leukemia, breast cancer, liver cancer and gastric cancer [15–18,44–48]. This evidence concerns the gene SNHG3 and pachyonychia congenita.