More specifically, inadequate activation and dysregulation of the hepatic XBP1 pathway has been implicated in NASH [3] and we have previously demonstrated that when fed a high fat sugar (HFS) diet, mice lacking hepatic XBP1 develop increased liver injury and fibrosis compared to control XBP1 flox mice [4]. The gene discussed is XBP1; the disease is metabolic dysfunction-associated steatohepatitis.