In the multiple logistic regression analysis, both pleural CEA and HA discriminated MM from LC with hazard ratios of 252.3 (95% CI: 16.4–3888.1, P < .001) and 23.6 (95% CI: 2.437–228.1, P = .006), respectively (Table 3). The gene discussed is CEACAM5; the disease is laryngotracheoesophageal cleft.