In addition, METL14-mediated regulation of PTEN-induced activation of this pathway significantly affected the HDAC-induced epithelial–mesenchymal transition (EMT) of renal tubular cells in DKD.[48] In addition, this pathway is related to the degree of renal fibrosis and glomerular podocyte damage.[49–52]. The gene discussed is PTEN; the disease is diabetic kidney disease.