A previous study identified an close relationship between rs2305948 and coronary heart disease.[30] In addition, a close relationship between rs2305948 and myocardial infarction in Caucasians has also been identified.[31] Another study documented a close association between susceptibility to stroke and rs2305948.[32] Many case-control studies on the relationship between the VEGFR2 polymorphism rs2305948 and glioma risk have been conducted, but the conclusions have not been consistent. This evidence concerns the gene KDR and central nervous system cancer.