VEGFA and central nervous system cancer: Vascular endothelial cell growth factor (VEGF) and VEGF receptor 2 (VEGFR2) are closely related to angiogenesis in glioma.[12,13] Main functions of VEGFR2 include increasing the expression of VEGF and inducing tumor angiogenesis.[14] In addition, VEGF plays a role in promoting vascular endothelial cell division and angiogenesis through VEGFR2 and is also involved in promoting the aggressive growth of tumors.