The overall analysis of 4 included studies showed that the association of the VEGFR2 gene polymorphism rs2305948 with susceptibility to glioma was not significant under each genetic model (allele: OR = 1.20, 95% CI = 0.93–1.54, P = .162; dominant: OR = 1.17, 95% CI = 0.93–1.46, P = .174; recessive: OR = 1.72, 95% CI = 0.94–3.15, P = .076; heterozygous: OR = 1.11, 95% CI = 0.94–1.30, P = .226; homozygous: OR = 1.74, 95% CI = 0.92–3.29, P = .088) (Fig. 2, Table 2). This evidence concerns the gene KDR and central nervous system cancer.