PGC1a could have tumor type–dependent effect in mitochondrial oxidation processes: PGC1a was described as a metastatic promoter expressed in circulating breast cancer cells [250]; however, its KO could increase the invasiveness of melanoma cells through focal adhesion kinase signaling, modulating cell–cell, cell–matrix connection, and support dissemination [251]. Here, PPARGC1A is linked to breast cancer.