When the IDH-mutant_1p/19qret gliomas were further subdivided in two subgroups (with and without AB/FS mismatch), significant differences were observed in four pairwise comparisons, after correction for multiple comparisons (Table 1, Fig. 4):(i)In IDH-wild-type vs IDH-mutant_1p/19qret with AB/FS mismatch, the highest AUC was achieved by the amine signal (0.97 for AB and 0.90 for FS), with thresholds of 0.89 (0.76) for the AB (FS), 93% (80%) sensitivity and 100% (89%) specificity. The gene discussed is IDH1; the disease is central nervous system cancer.