For example, circ_0000515 can adsorb miR-326 and promote the advancement of cervical cancer via up-regulating ELK1 expressions [14]; in breast cancer, reportedly, circ_0000515 participates in disease advancement via modulating miR-296-5p/CXCL10 axis [15]; circ_0000515 promotes the malignancy of hepatocellular carcinoma cells via decreasing MAPK10 expression [16]. The gene discussed is ELK1; the disease is hepatocellular carcinoma.