MEOX2 and hereditary sensory and autonomic neuropathy: MEOX2 mRNA dysregulation was reported in fibroblasts derived from Congenital Insensitivity to Pain (CIP) patients from two unrelated families with mutations D31Y and E172D in the transcription factor PR (PRDI‐BF1 and RIZ homology) domain containing member 12 (PRDM12) [8]. CIP is a rare genetic disorder affecting the survival or function of nociceptors, a specialised set of sensory neurons that detect pain, rendering patients unable to feel painful or noxious stimuli [9].