Here, we saw significant elevations in p‐Akt in both the CON (P = 0.025) and CKD derived myotubes (P = 0.041) in response to the 100 nM dose of IGF‐1 (Figure6B), with no significant differences noted in either donor group in response to the lower concentration or between the two donors (P = 0.265). Here, AKT1 is linked to chronic kidney disease.