KNG1 and neoplasm: Experimental evidence accumulated to date shows that gC1qR can interact with various molecules in the tumor cell environment, including proteins of the kinin system such as factor XII and high-molecular-weight kininogen (HK), thereby triggering activation of the kinin–kallikrein system (KKS) resulting in the generation of bradykinin—one of the most potent vasoactive peptides known78.