IDH1 and cancer: Comparing mutIDH1/2 with WT IDH1/2 cells has revealed alterations to central carbon metabolism, amino acid metabolism, lipid metabolism, and redox homeostasis.95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116 However, there is currently no consensus regarding the precise roles of these changes in relation to cancer development.