Glutamate dehydrogenase 1 (GLUD1) and GLUD2, which catalyze oxidative deamination of glutamate to 2-OG, are significantly elevated in mutIDH1R132H glioma compared with WT IDH1 glioma,104,212,213,221,222 indicating the potential for increased glutamate utilization by the TCA cycle. Here, IDH1 is linked to central nervous system cancer.