MutIDH glioma cells had increased expression of the de novo cholesterol synthesis enzymes 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) and sterole regulatory element-binding protein 2 (SREBP2), and inhibition of HMGCR by atorvastatin led to significant cell death in mutIDH1R132G-expressing U87 and U251 cells but had little effect on the WT IDH1-expressing U87 and U251 cells.115. This evidence concerns the gene IDH1 and central nervous system cancer.