IDH2 and central nervous system cancer: In contrast with glioma cells bearing IDH mutations, there are several cell lines derived from chondrosarcomas that harbor endogenous mutIDH1 or mutIDH2 with little to no stability issues; e.g., HT1080 and L835 (IDH1R132C), JJ012 (IDH1R132G), CS1 (IDH2R172S), and SW1353 (IDH2R172K).95