,173,212 Cultured mutIDH1R132H NHA and glioma (BT142) cells have reduced expression of the mono-carboxylate exporters MCT-1 and MCT-4 compared with WT IDH glioma cells (NHA and U87),216,217 supporting the hypothesis that mutIDH1 gliomas are less glycolytic than WT IDH1 gliomas. The gene discussed is IDH2; the disease is central nervous system cancer.