IDH1 and cancer: L-2-HGA and D-2-HGA are associated with neurological abnormalities, including developmental delay, epilepsy, and cerebral ataxia, as well as cardiomyopathy in individuals with D-2-HGA.152, 153, 154, 155, 156, 157 Interestingly, there appears to be a lack of association between D-2-HGA and cancer types commonly reported to have mutations in IDH1 and IDH2.158