It has been reported that insulin resistance inducers, including tumor necrosis factor (TNF)-α, reduced the activities and/or expressions of lipoprotein lipase (Lpl), an enzyme associated with triglyceride uptake in adipocytes [1,2]; glycerol-3-phosphate dehydrogenase 1 (Gpd1) and diacylglycerol transferase 1 (Dgat1), enzymes involved in triglyceride synthesis [3,4]; Cidec, an enzyme involved in lipid droplet production [5]; and adiponectin (Adipoq), an insulin sensitivity hormone [6]. Here, GPD1 is linked to Insulin resistance.