CD8A and neoplasm: Furthermore, we demonstrated that the binding of the chimeric PDL1-scFv-Fc-RE7 protein by PD-L1-expressing tumor cell led to the release of E7-specific CTL epitope and the presentation of the E7 CTL epitope by the MHC-I molecules of tumor cells, rendering them susceptible to E7-specific CTL-mediated killing by preexisting E7-specific CD8+ T cells generated by CRTE7 DNA vaccine.