Neutrophils release prostaglandin E2 (PGE2) to amplify inflammation and create a tumor microenvironment, which can promote colon tumorigenesis, suppress activities of natural killer cells, and increase the exudation of tumor cells through the secretion of interleukin-1β(IL-1β) and matrix metalloproteinases (MMP) [16]. The gene discussed is IL1B; the disease is neoplasm.