The multivariate Cox proportional hazards model analysis result showed that the age over 65, being male, N1–N2, M1 stage, and low BMI were independent risk factors for poor prognosis of CRC, without stratified analysis, NLR, PLR, and CEA level cannot be determined as independent risk factors for the prognosis of CRC. The gene discussed is CEACAM5; the disease is colorectal carcinoma.