NPPB and hydrops fetalis: In 2019, Morrow et al. conducted the Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode (PIONEER-HF) trial to study if sacubitril/valsartan reduced N-terminal Pro-b-type natriuretic peptide (NT-Pro-BNP) levels during acute HF decompensation [41].