The chemical spectra and lipid-lowering efficacies of ARD extracts in HepG2 cells with different compatibilities were correlated to reveal the core lipid-lowering compounds, and their potential interactions with FXR were then determined by molecular docking in order to verify the accuracy of spectrum-effect analysis and probe the mechanism of action of ARD on hyperlipidemia. This evidence concerns the gene NR1H4 and hyperlipidemia.