IL6 and serum lipopolysaccharide activity: It is worth noting that CGP-60474, an inhibitor of cyclin-dependent kinase, has proved to be the most potential drug in that it alleviated tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in activated macrophages by downregulating the NF_κB activity and reducing the mortality rate in LPS-induced endotoxemia mice [63].