C4A and systemic lupus erythematosus: If degradation of NETs is incomplete, residual NETs mediate inflammasome and complement activation; for example, lower concentrations of complement factors C3 and C4 were found in SLE patients, indicating consumption of complement and SLE-related NET complement activation, triggering the accumulation of C1q on NETs, which further inhibits DNase1 [52, 53].