To validate the gamma oscillation deficit as a feature of cognitive impairment, we investigated whether deficits in gamma oscillation in PSAPP mice could be rescued by the AChE inhibitor donepezil, which has been approved for the palliative treatment of cognitive impairment in AD patients (Whitehead et al., 2004; Birks and Harvey, 2018). The gene discussed is ACHE; the disease is Alzheimer disease.