In this study, we show that transient hyperglycemia-mediated oxidative stress suppresses the expression of RORA, CYP19A1, and SOD2; prenatal RORA deficiency mimics maternal diabetes-mediated ALB, and postnatal RORA manipulation in the amygdala modulates maternal diabetes-mediated ALB in offspring. The gene discussed is CYP19A1; the disease is Hyperglycemia.