The results showed that RORE mutation (M-183/RORE/HG) completely reversed hyperglycemia-mediated CYP19A1 suppression, indicating that hyperglycemia suppresses CYP19A1 through the RORE element (located at −183) on the CYP19A1 promoter (see Fig. 3d). The gene discussed is CYP19A1; the disease is Hyperglycemia.