The results showed that maternal diabetes (STZ/P-VEH) significantly decreased CSF estradiol (E2) levels (see Fig. 6d) and ER activity in the amygdala (see Fig. 6e), while RORA expression in the amygdala (STZ/P- ↑ RORA) completely reversed, while RORA knockdown in the amygdala (CTL/P-shRORA) mimicked, maternal diabetes-mediated ER activity, but had little effect on CSF E2 levels. The gene discussed is RORA; the disease is diabetes mellitus.