RORA and diabetes mellitus: The results showed that maternal diabetes (CTL/WT) significantly decreased SYP expression, including mRNA (see Fig. 5g) and protein (see Fig. 5h, i, Supplementary Fig. 1d) levels, as well as spine density (see Fig. 5j, k), compared to the control (CTL/WT) group, and prenatal RORA deficiency (RORA−/−) treatment mimicked this effect.