The results showed that hyperglycemia-mediated CYP19A1 reporter suppression occurred in the −2000, −1600, −1200, −800, −600, −400, and −200 deletion constructs (numbered according to Ensembl gene ID: CYP19A1-201 ENST00000396402.6; TSS was marked as 0), while the suppression disappeared in the −100 deletion construct, indicating that hyperglycemia-responsive element was located in the range of −200 to −100 on the CYP19A1 promoter (see Fig. 3a). Here, CYP19A1 is linked to Hyperglycemia.