RORA and Hyperglycemia: Our results showed that hyperglycemia-mediated RORA reporter suppression occurred in the −2000, −1600, −1200, −800, −600, −400, and −300 deletion constructs (numbered according to Ensembl gene ID: RORA-201 ENST00000261523.9; transcription start site (TSS) was marked as 0), while the suppression completely disappeared in the −200 and subsequent deletion reporter constructs, suggesting that hyperglycemia-responsive transcriptional element is located in the range of −300 to −200 on the RORA promoter (see Fig. 2a).