The reporter assay showed that hyperglycemia-induced reporter suppression disappeared in two of the OCT mutation constructs (located at −276 and −251, respectively, marked in green, see Fig. 2b), suggesting that hyperglycemia mediates RORA suppression through the OCT binding motif on the RORA promoter (see Fig. 2c). This evidence concerns the gene PLXNA2 and Hyperglycemia.