SOD2 and Hyperglycemia: Infection of RORA expression lentivirus on day 5 (HG(4d)+LG(4d)/↑RORA) significantly increased RORA expression and completely restored hyperglycemia-induced suppression of CYP19A1 and SOD2, while infection of RORA knockdown lentivirus on day 5 (LG(4d)+LG(4d)/shRORA) significantly decreased expression of RORA, CYP19A1, and SOD2 compared to the control (LG(4d)+LG(4d)/CTL) group, and mRNA levels of RORA, CYP19A1, and SOD2 on day 8 are presented in Fig. 1c.