CTLA4 and neoplasm: High inflammation MIBC tumors also showed significant upregulation of the IFN-γ-inducible ICGs IDO1 and PD-L1 as well as the ICGs CTLA-4 and LAG3. The stimulation of these ICGs likely facilitates MIBC pro-tumor immune tolerance, suggesting that immune checkpoint blockade therapies could be more suitable for MIBC patients with high- compared to low- inflammation.