Notably, genes mediated by IFN-γ, a key cytokine in the tumor microenvironment were also significantly upregulated in high inflammation (STAT1, CCR5, CXCL9, CXCL10, CXCL11, CCL2, CCL4, CCL5, CCL13, CCL17, CCL18, CCL19, CCL21, CCL22, IDO1, PRF1, IRF4, IRF8, GZMA, HLA-DRA, HLA-DMA, Fig. 3B). Here, STAT1 is linked to neoplasm.