Notably, genes mediated by IFN-γ, a key cytokine in the tumor microenvironment were also significantly upregulated in high inflammation (STAT1, CCR5, CXCL9, CXCL10, CXCL11, CCL2, CCL4, CCL5, CCL13, CCL17, CCL18, CCL19, CCL21, CCL22, IDO1, PRF1, IRF4, IRF8, GZMA, HLA-DRA, HLA-DMA, Fig. 3B). This evidence concerns the gene IRF4 and neoplasm.