Notably, genes mediated by IFN-γ, a key cytokine in the tumor microenvironment were also significantly upregulated in high inflammation (STAT1, CCR5, CXCL9, CXCL10, CXCL11, CCL2, CCL4, CCL5, CCL13, CCL17, CCL18, CCL19, CCL21, CCL22, IDO1, PRF1, IRF4, IRF8, GZMA, HLA-DRA, HLA-DMA, Fig. 3B). The gene discussed is PRF1; the disease is neoplasm.