Notably, individuals carrying the TYR p.(Met252Arg) variant on one allele and only the p.(Arg402Gln) or the p.(Ser192Tyr) variant on the other allele were apparently unaffected with no clinical features of OCA (individuals VIII:9, IX:2, IX:21, X:6, X:8, IX:1 and IX:4; Fig. 1a). This evidence concerns the gene TYR and oculocutaneous albinism.