At the same time, 13 individuals who were compound heterozygous for TYR p.(Met252Arg) and p.(Ser192Tyr)/p.(Arg402Gln) alleles all displayed clinical features of partial albinism, suggesting an additive impact of the p.(Ser192Tyr) and p.(Arg402Gln) variants on tyrosinase function. Here, TYR is linked to piebaldism.