To clarify the relationship between HBXIP and anoikis in breast cancer cells, we first evaluated the variations in HBXIP expression in MCF-7 (which have relatively low HBXIP expression levels) and MDA-MB-436 (which have relatively high HBXIP expression levels) cells following ECM detachment (Supplementary Fig. 1A). This evidence concerns the gene LAMTOR5 and breast carcinoma.