The HBXIP/Nrf2 axis promotes ECM-detached breast cancer cell survival by reducing cellular ROS accumulation and stabilizing Prdx1, which inhibits the release of JNK1 from Prdx1-GSTπ-JNK heterotrimeric complexes and prevents JNK1 activation (Fig. 7). This evidence concerns the gene MAPK8 and breast carcinoma.