CALR and ductal breast carcinoma in situ: The downregulation of components of the Calreticulin-Calnexin cycle in the epithelium in Excluded state could impact MHC-I export or maturation, as suggested by the lack of MHC-I expression induction in DCIS of the eExcluded state, hence providing an evasion mechanism, and contrasting with evasion mediated by MHC-I genetic loss observed in IBC54,55.