Consistent with previous studies, loss of 16q (13/30) and 17p (12/30) or gain of 1q (12/30) were among the most frequent chromosomal alterations and, while many events were more frequent in HG-DCIS (Fig. 2c, Supplementary Table 4), these hallmarks were also observed in low-grade or benign lesions, including ADH: (1q gain: 1/9, 16q loss: 7/9, 17p loss: 3/9). The gene discussed is AVP; the disease is ductal breast carcinoma in situ.