Consistent with this, we and others have found altered expression of NF-κB pathway mRNAs in the post-mortem cerebral cortex of people with schizophrenia [12, 14], and we showed that individuals with increased levels of NF-κB-inducing mRNAs also have increased levels of pro-inflammatory cytokine transcripts in the brain (for a detailed explanation of NF-κB-signaling pathways, see Fig. 1). Here, NFKB1 is linked to schizophrenia.