Individual gene product links to adipocyte function and metabolism ranged from formyl peptide receptor 1 (Fpr1) that interacts with gut-microbiota generated N-formyl peptide to promote obesity-linked glucose intolerance38 to protein tyrosine phosphatase receptor type V (Ptprv) that regulates insulin secretion39 to Nos1ap that increases oxidative stress in diabetes40 and contributes to adipose tissue beiging41. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.