LMNA and familial partial lipodystrophy, Dunnigan type: Mutations in the LMNA gene that encodes A-type lamins (principally lamins A and C) cause familial partial lipodystrophy of the Dunnigan-type (FPLD2)7,8, a more severe lipodystrophy9, several metabolic syndromes10,11, and type 2 diabetes12,13.