To further explore whether CXCL5 regulates exosomal HSPC111 excretion in CRC cells, we stimulated CRC cells with recombinant human CXCL5, and found that the protein level of HSPC111 was elevated dose-dependently in CRC cells and their derived exosomes, respectively (Supplementary Fig. S5A, B). This evidence concerns the gene NOP16 and colorectal carcinoma.