Additionally, incubation of a CXCL5-neutralizing antibody with CM-ExoHCT116 KD in HCT116 cells and CM-ExoSW480 OE in SW480 cells not only reduced HSPC111, CXCR2 and E-cadherin expression and elevated Vimentin and Snail expression (Fig. 7E, F), but also hindered the cell migration of CRC cells (Fig. 7G and Supplementary Fig. S5C). Here, CXCL5 is linked to colorectal carcinoma.