CXCR2 and colorectal carcinoma: Additionally, incubation of a CXCL5-neutralizing antibody with CM-ExoHCT116 KD in HCT116 cells and CM-ExoSW480 OE in SW480 cells not only reduced HSPC111, CXCR2 and E-cadherin expression and elevated Vimentin and Snail expression (Fig. 7E, F), but also hindered the cell migration of CRC cells (Fig. 7G and Supplementary Fig. S5C).