To verify whether CXCL5-CXCR2 axis promotes CRC cells migration by inducing EMT, we found that CM-ExoHCT116 KD incubation led to higher expression of E-cadherin and lower expression of Vimentin and Snail in HCT116 cells (Fig. 7A–E). The gene discussed is CXCR2; the disease is colorectal carcinoma.