For example, SRSF1 regulates the alternative splicing of the tumor suppressor BIN1, which interacts with the proto-oncogene MYC to inhibit its proliferative activity [31], while SRSF1 overexpression endorses BIN1 exon12a inclusion that lacks tumor-suppressor activity due to reduced binding with MYC [44]. This evidence concerns the gene BIN1 and neoplasm.