TIAM1 and colorectal carcinoma: Zhang also found that hsa_circ_0020397 can regulate the expression of miR-138 by targeting TERT and PD-L1 and then handle the apoptosis of CRC cells [17] He et al. found that circRNA-ACAP2 can regulate the apoptosis of CRC cells through the hsa-miR-21-5p/Tiam1 signal axis [18].