A similar DSB repair defect was observed with ectopic expression of SF3B1K700E in SF3B1 wild-type cells and a mesothelioma-derived cell line harboring the SF3B1K700E mutation (H2595) compared with a matched SF3B1 wild-type control mesothelioma-derived line (H2591; Supplementary Fig. S2B–S2D). Here, SF3B1 is linked to mesothelioma.